L. Kozhaya

Engineering human Mucosal Associated Invariant T (MAIT) cells with chimeric antigen receptors for cancer immunotherapy

This paper engineers MAIT cells with CARs to target cancer cells, showing comparable cytotoxicity to CD8+ CAR-T cells but with lower IFN-γ expression.

3D Bioprinted perfusable and vascularized breast tumor model for dynamic screening of chemotherapeutics and CAR-T cells

This paper develops a 3D bioprinted vascularized breast tumor model to dynamically screen chemotherapeutics and CAR-T cells, showing dose-dependent drug response and significant tumor reduction with CAR-T treatment.

Modulation of glucose metabolism by 2-Deoxy-D-Glucose (2DG) promotes IL-17 producing human T cell subsets

This study shows that 2DG inhibits glycolysis in human T cells, increasing IL-17-producing subsets like Th17 and MAIT cells, with effects reversed by mannose.

Development of 3D breast cancer models with human T cells expressing engineered MAIT cell receptors

This study develops 3D breast cancer models with engineered MAIT cell receptors to assess their cytotoxic activity against tumor cells.

Targeting SARS-CoV-2 infection through CAR-T like bispecific T cell engagers incorporating ACE2

This paper develops a bispecific T cell engager (ACE2-Bite) that targets SARS-CoV-2 infected cells and neutralizes variants, showing higher affinity for Delta and Omicron.

Perturbation of effector and regulatory T cell subsets in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)

This study identifies altered T cell subset frequencies and functions in ME/CFS patients, suggesting chronic immune activation and potential biomarkers.

Structure-Based Discovery of a Novel Small-Molecule Inhibitor of Methicillin-Resistant S. aureus

This study identifies C14PC as a potential antivirulence agent against MRSA by protecting immune cells from PVL and -toxin cytotoxicity.