Author

L. Placek

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Immunology· 3 Biochemistry· 1 Bioengineering· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 5 Assay:proteomics· 4 Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:benchmarking· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

D. Unutmaz· 5 shared L. Kozhaya· 4 shared E. Karhan· 3 shared M. Dogan· 2 shared M. Yigit· 2 shared X. Chen· 2 shared C. Gunter· 1 shared C. Wang· 1 shared

Activity by Year

2019-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

5 shared papersImmunology

D. Unutmaz

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Engineering human Mucosal Associated Invariant T (MAIT) cells with chimeric antigen receptors for cancer immunotherapy

M. Dogan, E. Karhan, L. Kozhaya, L. Placek, X. Chen, M. Yigit, D. Unutmaz

This paper engineers MAIT cells with CARs to target cancer cells, showing comparable cytotoxicity to CD8+ CAR-T cells but with lower IFN-γ expression.

bioRxiv · Jul 28, 2022 · PreprintImmunology

Modulation of glucose metabolism by 2-Deoxy-D-Glucose (2DG) promotes IL-17 producing human T cell subsets

X. Chen, L. Kozhaya, C. Wang, L. Placek, E. Karhan, D. Unutmaz

This study shows that 2DG inhibits glycolysis in human T cells, increasing IL-17-producing subsets like Th17 and MAIT cells, with effects reversed by mannose.

bioRxiv · Mar 13, 2022 · PreprintImmunology

Targeting SARS-CoV-2 infection through CAR-T like bispecific T cell engagers incorporating ACE2

M. Dogan, L. Kozhaya, L. Placek, F. Karabacak, M. Yigit, D. Unutmaz

This paper develops a bispecific T cell engager (ACE2-Bite) that targets SARS-CoV-2 infected cells and neutralizes variants, showing higher affinity for Delta and Omicron.

bioRxiv · Jan 19, 2022Bioengineering

Perturbation of effector and regulatory T cell subsets in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)

E. Karhan, C. Gunter, V. Ravanmehr, M. Horne, L. Kozhaya, S. Renzullo, L. Placek, J. George, P. N. Robinson, S. D. Vernon, L. Bateman, D. Unutmaz

This study identifies altered T cell subset frequencies and functions in ME/CFS patients, suggesting chronic immune activation and potential biomarkers.

bioRxiv · Dec 23, 2019 · PreprintImmunology

Live cell kinetic analysis of the LMO2/LDB1 leukemogenic protein complex reveals a hierarchy of turnover with implications for complex assembly

J. H. Layer, M. Christy, L. Placek, D. Unutmaz, Y. Guo, U. Dave

The paper analyzes the kinetic stability of the LMO2/LDB1 complex subunits and identifies LDB1 as a stabilizer and nucleator of the complex.

bioRxiv · Jul 21, 2019 · PreprintBiochemistry