L. L. P. Hosszu

Alanine replacements in the structured C-terminal domain of the prion protein reveal conformationally variable regions as major determinants for prion propagation

This study uses alanine mutagenesis to identify conformationally variable regions in PrPC that are critical for prion propagation.

Loss of the first β-strand of human prion protein generates an aggregation-competent partially "open" form

This study examines the structural and functional changes in a truncated form of human prion protein lacking a conserved membrane region, showing it forms fibrils more readily than the native form.