Author

A. R. Clarke

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 2 Biochemistry· 1 Cell Biology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Assay:DNA methylation· 1

Frequent Co-Authors

A. J. Hollins· 1 shared A. W. Foster· 1 shared B. Herpers· 1 shared B. Missenden· 1 shared B. Shorning· 1 shared C. Esdar· 1 shared C. G. Manawaduge· 1 shared D. A. Badder· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperCancer Biology

A. J. Hollins

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Strong genetic differentiation but limited niche partitioning in a sympatric species pair separated by an allochronic reproductive barrier

M. Irvine, Z. Stewart, N. Kumaran, C. G. Manawaduge, J. L. Ryan, S. Balagawi, B. Missenden, M. Starkie, A. R. Clarke, D. A. Hurwood, P. Prentis

This study examines a sympatric fruit fly species pair, finding strong genetic differentiation but limited ecological niche partitioning, with assortative mating playing a key role in maintaining species boundaries.

bioRxiv · Aug 30, 2023Evolutionary Biology

Alanine replacements in the structured C-terminal domain of the prion protein reveal conformationally variable regions as major determinants for prion propagation

S. K. Bhamra, P. Arora, L. L. P. Hosszu, J. Bieschke, A. R. Clarke, J. Collinge, P. Jat

This study uses alanine mutagenesis to identify conformationally variable regions in PrPC that are critical for prion propagation.

bioRxiv · Jan 19, 2023 · PreprintBiochemistry

Metalation calculators for E. coli strain JM109 (DE3): Aerobic, anaerobic and hydrogen peroxide exposed cells cultured in LB media

N. J. Robinson, A. W. Foster, S. E. Clough, T. R. Young, A. R. Clarke, Z. Aki

The paper develops web-based calculators and spreadsheets to predict metal occupancies in E. coli cells under different growth conditions using metal-affinity data and gene expression measurements.

bioRxiv · May 6, 2022Cell Biology

Plexin-B1 mutation drives prostate cancer metastasis

B. Shorning, N. Trent, D. F. Griffiths, T. Worzfeld, S. Offermanns, J. Masters, A. R. Clarke, M. J. Smalley, M. Williamson

This study shows that a Plexin-B1 mutation promotes prostate cancer metastasis and identifies it as a potential therapeutic target.

bioRxiv · Jul 19, 2020 · PreprintCancer Biology

3D imaging of colorectal cancer organoids identifies responses to Tankyrase inhibitors

L. M. Badder, A. J. Hollins, B. Herpers, K. Yan, K. B. Ewan, J. R. Shone, D. A. Badder, M. Naven, K. Ashelford, R. Hargest, A. R. Clarke, C. Esdar, H.-P. Buchstaller, D. Wienke, L. S. Price, , T. Dale

This study uses 3D colorectal cancer organoids to assess responses to Tankyrase inhibitors, showing morphometric analysis can detect drug effects on cancer stem cells.

bioRxiv · Jul 18, 2019Cancer Biology