Global kinome silencing combined with 3D invasion screening of the tumor microenvironment identifies fibroblast-expressed PIK3Cδ involvement in triple-negative breast cancer progression
T. Gagliano, K. Shah, S. Gargani, L. Lao, M. Alsaleem, J. Chen, V. Ntafis, P. Huang, A. Ditsiou, V. Vella, K. Yadav, K. Bienkowska, G. Bresciani, K. Kang, L. Li, , G. Giamas
The paper identifies fibroblast-expressed PIK3Cδ as a key driver of triple-negative breast cancer progression through paracrine signaling and shows its prognostic significance.
bioRxiv · Nov 2, 2019 · PreprintCancer Biology