A. R. Green

Adaptation to ex vivo culture drives human haematopoietic stem cell loss of repopulation capacity in a cell cycle independent manner

This study shows that human LT-HSC loss of repopulation capacity during ex vivo culture occurs rapidly after adaptation, independent of cell cycle progression.

Utility of stromal lymphocytes in diagnosis and predicting upgrade of B3 breast lesions from core biopsies

This study identifies stromal lymphocytes as a biomarker to predict upgrade of B3 breast lesions from core biopsies, with high specificity.

RANK is an independent biomarker of poor prognosis in estrogen receptor-negative breast cancer and a therapeutic target in patient-derived xenografts

This study shows RANK is a poor prognosis biomarker in ER-negative breast cancer and that targeting RANK improves outcomes in patient-derived xenografts.

Epigenome erosion drives neural crest-like phenotypic mimicry in triple-negative breast cancer and other SOX10+ malignancies

The paper identifies SOX10 expression in TNBC and other SOX10+ malignancies, linking it to epigenome erosion and neural crest-like phenotypic mimicry through promoter hypomethylation.

Phylogenetic reconstruction of myeloproliferative neoplasm reveals very early origins and lifelong evolution

This study reconstructs the phylogeny of myeloproliferative neoplasms using whole-genome sequencing, revealing early mutation acquisition and lifelong clonal evolution leading to cancer.

Global kinome silencing combined with 3D invasion screening of the tumor microenvironment identifies fibroblast-expressed PIK3Cδ involvement in triple-negative breast cancer progression

The paper identifies fibroblast-expressed PIK3Cδ as a key driver of triple-negative breast cancer progression through paracrine signaling and shows its prognostic significance.