L. Leisle

Backbone amides are key determinants of Cl- selectivity in CLC ion channels

The paper shows that backbone amides in CLC channels are critical for Cl- selectivity, as replacing them with ester groups reduces ion discrimination.

Divergent Cl-and H + pathways underlie transport coupling and gating in CLC exchangers and channels

This study identifies an aromatic pathway in CLC proteins that enables H+ transport and gating, revealing distinct and conserved routes for Cl- and H+ movement.