Author

J. D. Galpin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Research Focus:cell signaling & trafficking· 1 Organism:E. coli· 1 Assay:electrophysiology· 1 Organism:human· 1 Assay:proteomics· 1 Approach:simulation· 1

Frequent Co-Authors

C. A. Ahern· 3 shared A. Accardi· 2 shared E. Fortea· 2 shared E. Tajkhorshid· 2 shared L. Leisle· 2 shared A. Rasouli· 1 shared C. J. Clark· 1 shared D. T. Infield· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersBiochemistry

C. A. Ahern

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Author profile →

3 papers

Recent·Most cited

Backbone amides are key determinants of Cl- selectivity in CLC ion channels

L. Leisle, K. Lam, S. Dehghanighahnaviyeh, E. Fortea, J. D. Galpin, C. A. Ahern, E. Tajkhorshid, A. Accardi

The paper shows that backbone amides in CLC channels are critical for Cl- selectivity, as replacing them with ester groups reduces ion discrimination.

bioRxiv · Jul 1, 2022 · PreprintBiophysics

Tuning aromatic contributions by site-specific encoding of fluorinated phenylalanine residues in bacterial and mammalian cells

G. D. Galles, D. T. Infield, C. J. Clark, M. L. Hemshorn, S. Manikandan, F. S. Fazan, A. Rasouli, E. Tajkhorshid, J. D. Galpin, R. B. Cooley, R. A. Mehl, C. A. Ahern

This paper introduces new pyrrolysine-based aminoacyl-tRNA synthetase/tRNA pairs to site-specifically encode fluorinated phenylalanine residues in bacterial and mammalian cells, enabling experimental assessment of aromatic-pi interactions.

bioRxiv · Apr 12, 2022 · PreprintBiochemistry

Divergent Cl-and H + pathways underlie transport coupling and gating in CLC exchangers and channels

A. Accardi, L. Leisle, Y. Xu, E. Fortea, J. D. Galpin, M. Vien, C. A. Ahern, S. Berneche

This study identifies an aromatic pathway in CLC proteins that enables H+ transport and gating, revealing distinct and conserved routes for Cl- and H+ movement.

bioRxiv · Sep 5, 2019Biochemistry