The heme precursor 5-aminolevulinic acid triggers the shutdown of the HemKR signalling system in Leptospira
J. A. Imelio, F. Trajtenberg, S. Mondino, L. Zarantonelli, I. Vitrenko, L. Lemee, T. Cokelaer, M. Picardeau, A. Buschiazzo
This study shows that 5-aminolevulinic acid triggers shutdown of the HemKR signaling system in Leptospira by promoting HemK phosphatase activity, leading to gene expression changes and iron-deficit tolerance.
bioRxiv · Oct 19, 2023 · PreprintMicrobiology