M. Picardeau

Evolutionary insights into the emergence of virulent Leptospira spirochetes

This study identifies genetic and phenotypic traits associated with virulence in Leptospira by comparing environmental and pathogenic strains.

The heme precursor 5-aminolevulinic acid triggers the shutdown of the HemKR signalling system in Leptospira

This study shows that 5-aminolevulinic acid triggers shutdown of the HemKR signaling system in Leptospira by promoting HemK phosphatase activity, leading to gene expression changes and iron-deficit tolerance.

Pan-species transcriptomic analysis reveals a constitutive adaptation against oxidative stress for the highly virulent Leptospira species.

The paper introduces Annotator-RNAtor for pan-species transcriptomic analysis and applies it to study adaptation in Leptospira species, finding higher katE expression in virulent P1+ strains linked to oxidative stress tolerance.

Core genome sequencing and genotyping of Leptospira interrogans in clinical samples by target capture sequencing

This study uses target capture sequencing to genotype Leptospira interrogans strains from clinical samples, identifying key serovars with high coverage and accuracy.

The oxidative stress response of pathogenic Leptospira is controlled by two peroxide stress regulators which putatively cooperate in controlling virulence.

This study identifies and characterizes a second peroxide stress regulator, PerRB, in Leptospira, showing that PerRA and PerRB cooperatively regulate virulence through oxidative stress adaptation.

The FUR-like regulators PerRA and PerRB integrate a complex regulatory network that promotes mammalian host-adaptation and virulence of Leptospira interrogans.

This study identifies PerRA and PerRB as key regulators in Leptospira interrogans that enhance host adaptation and virulence through complex gene regulation networks.

Escape of TLR5 Recognition by Leptospira spp: A Rationale for Atypical Endoflagella

This study investigates TLR5 recognition of Leptospira spp. and finds that their flagellins are highly stable and centrally located, allowing them to evade TLR5 detection.

The adaptive transcriptional response of pathogenic Leptospira to peroxide reveals new defenses against infection-related oxidative stress

This study identifies the adaptive transcriptional response of Leptospira to peroxide stress, revealing key defense mechanisms against oxidative stress during infection.

An asymmetric sheath controls flagellar supercoiling and motility in the Leptospira spirochete

The paper determines the structure of Leptospira flagellar filaments, revealing an asymmetric sheath that controls supercoiling and motility.