T. Cokelaer

The heme precursor 5-aminolevulinic acid triggers the shutdown of the HemKR signalling system in Leptospira

This study shows that 5-aminolevulinic acid triggers shutdown of the HemKR signaling system in Leptospira by promoting HemK phosphatase activity, leading to gene expression changes and iron-deficit tolerance.

Metabolic reprogramming during Candida albicans planktonic-biofilm transition is modulated by the ZCF15 and ZCF26 paralogs

This study identifies ZCF15 and ZCF26 as biofilm regulators in Candida albicans that modulate metabolic reprogramming during the planktonic-to-biofilm transition.

Bile-induced biofilm formation in Bacteroides thetaiotaomicron requires magnesium efflux by an RND pump

This paper identifies a bile-induced RND efflux pump in Bacteroides thetaiotaomicron that facilitates magnesium efflux, reducing eDNA concentration and promoting biofilm formation.

Mtfp1 ablation enhances mitochondrial respiration and protects against hepatic steatosis

This study shows that deleting Mtfp1 in hepatocytes increases mitochondrial respiration and protects against fatty liver disease.

Gallocin A, an atypical two-peptide bacteriocin with intramolecular disulfide bonds required for activity

This paper characterizes gallocin A, a two-peptide bacteriocin from SGG, showing it requires intramolecular disulfide bonds for activity and that its immunity peptide shares structural features with the toxin.

Core genome sequencing and genotyping of Leptospira interrogans in clinical samples by target capture sequencing

This study uses target capture sequencing to genotype Leptospira interrogans strains from clinical samples, identifying key serovars with high coverage and accuracy.

Experimental evolution reveals post-transcriptional regulation as a novel driver of Leishmania fitness gain

This study shows that post-transcriptional regulation, not just genome instability, drives fitness gain in Leishmania parasites during in vitro adaptation.

Autotransporters drive biofilm formation and auto-aggregation in the diderm Firmicute Veillonella parvula

This study identifies autotransporters as key drivers of biofilm formation and auto-aggregation in Veillonella parvula using genetic tools and functional analyses.

GDSCTools for Mining Pharmacogenomic Interactions in Cancer

GDSCTools provides a software package for analyzing pharmacogenomic data to identify genomic markers of drug response in cancer.

Dissecting cancer resistance to therapies with cell-type-specific dynamic logic models

The paper uses dynamic logic models of signaling pathways to predict drug sensitivity in colorectal cancer cell lines and identifies drug combinations to overcome resistance.