Author

L. M. Amzel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Approach:mechanistic / dynamical model· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Research Focus:development & morphogenesis· 1 Assay:DNA methylation· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

A. Y. Lau· 1 shared E. Karakas· 1 shared F. J. Sigworth· 1 shared G. Salazar de Simone· 1 shared H. Saavedra· 1 shared J. P. Nicola· 1 shared L. Albacarys· 1 shared M. A. Bianchet· 1 shared

Activity by Year

2022-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperBiophysics

A. Y. Lau

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Author profile →

3 papers

Recent·Most cited

NIS metastable intermediates provide insights into conformational transition between principal thermodynamic states

M. Chakrabarti, L. M. Amzel, A. Y. Lau

This study uses enhanced sampling and MD simulations to identify intermediate states of NIS during conformational transitions between inwardly and outwardly open states.

bioRxiv · Oct 13, 2022 · PreprintBiophysics

Mammalian D-Cysteine controls insulin secretion in the pancreas

R. Roychaudhuri, T. West, S. Bhattacharya, H. Saavedra, L. Albacarys, M. M. Gadalla, L. M. Amzel, P. Yang, S. H. Snyder

This paper identifies D-cysteine as a regulator of insulin secretion in the pancreas, showing its role in modulating cAMP, CREB, and DNA methylation in islets.

bioRxiv · May 17, 2022Biochemistry

Structural insights into the mechanism of the sodium/iodide symporter (NIS)

S. Ravera, J. P. Nicola, G. Salazar de Simone, F. J. Sigworth, E. Karakas, L. M. Amzel, M. A. Bianchet, N. Carrasco

This study reports three cryo-EM structures of rat NIS, revealing substrate binding sites and transport mechanisms, and provides insights into anion selection and translocation.

bioRxiv · Apr 7, 2022Biophysics