Author

L. M. Meikle

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 1 Assay:metabolomics· 1

Frequent Co-Authors

D. M. Wall· 3 shared M. J. Ormsby· 2 shared A. J. Roe· 1 shared A. McIntosh· 1 shared A. S. MacDonald· 1 shared C. C. McConnachie· 1 shared C. Hasson· 1 shared D. G. Smith· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersMicrobiology

D. M. Wall

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3 papers

Recent·Most cited

Inhibition of proline tyrosine kinase 2 (Pyk2) phosphorylation during adherent-invasive Escherichia coli infection inhibits intra-macrophage replication and inflammatory cytokine release

X. Li, M. J. Ormsby, G. Fallata, L. M. Meikle, D. Xu, D. M. Wall

This study shows that inhibiting Pyk2 reduces AIEC replication in macrophages and inflammatory cytokine release, suggesting a potential therapeutic target for Crohn's Disease.

bioRxiv · Nov 14, 2022 · PreprintMicrobiology

Mapping the influence of the gut microbiota on small molecules in the brain through mass spectrometry imaging

D. M. Wall, H. Hulme, L. M. Meikle, N. Strittmatter, J. Swales, G. Hamm, S. L. Brown, S. Milling, A. S. MacDonald, R. J. Goodwin, R. Burchmore

This study uses mass spectrometry imaging to map microbial and host metabolites in the gut and brain of mice, finding altered metabolites in germ-free animals but not after antibiotic treatment.

bioRxiv · Mar 13, 2020 · PreprintMicrobiology

Propionic acid promotes the virulent phenotype of Crohns disease-associated adherent-invasive Escherichia coli

M. J. Ormsby, S. A. Johnson, L. M. Meikle, R. J. Goldstone, A. McIntosh, H. M. Wessel, H. E. Hulme, C. C. McConnachie, J. P. Connolly, A. J. Roe, C. Hasson, J. Boyd, E. Fitzgerald, K. Gerasimidis, D. Morrison, , D. M. Wall

This study shows that propionic acid exposure increases virulence in adherent-invasive Escherichia coli, leading to higher persistence in mice and altered gene expression.

bioRxiv · Dec 20, 2018Microbiology