S. L. Brown

BUB1 regulates non-homologous end joining pathway to mediate radioresistance in triple-negative breast cancer

This study identifies BUB1 as a regulator of non-homologous end joining (NHEJ) in triple-negative breast cancer (TNBC), showing that its inhibition sensitizes TNBC cells to radiotherapy.

BUB1 inhibition sensitizes lung cancer cell lines to radiotherapy and chemoradiotherapy

This study shows BUB1 inhibition enhances the effectiveness of radiotherapy and chemoradiation in lung cancer cell lines.

Divergent trajectories to structural diversity impact patient survival in high grade serous ovarian cancer

The paper identifies two divergent structural variation trajectories in HGSOC that impact patient survival and reveals novel candidate driver genes and mtDNA mutations associated with prognosis.

Mgl2+ cDC2s coordinate fungal allergic airway type 2, but not type 17, inflammation.

The paper identifies Mgl2+ cDC2s as key drivers of type 2, but not type 17, fungal allergic airway inflammation in mice.

Phase separation of both a plant virus movement protein and cellular factors support virus-host interactions

This paper shows that the p26 movement protein from PEMV2 undergoes phase separation, enabling virus-host interactions necessary for viral movement and that host protein phase separation can restrict virus replication.

IgM+ and IgM- memory B cells represent heterogeneous populations capable of producing class-switched antibodies and germinal center B cells upon re-challenge with P. yoelii.

The paper identifies IgM+ and IgM- memory B cells that can differentiate into plasmablasts and germinal center B cells upon re-challenge with P. yoelii.

Antibody interference by a non-neutralizing antibody abrogates humoral protection against Plasmodium liver stage

This study shows non-neutralizing antibodies can reduce the effectiveness of neutralizing antibodies against Plasmodium CSP, impacting vaccine efficacy in malaria-exposed individuals.

Mapping the influence of the gut microbiota on small molecules in the brain through mass spectrometry imaging

This study uses mass spectrometry imaging to map microbial and host metabolites in the gut and brain of mice, finding altered metabolites in germ-free animals but not after antibiotic treatment.