M. J. Ormsby

Genomic diversity of novel strains of mammalian gut microbiome derived Clostridium XIVa strains is driven by mobile genetic element acquisition

The paper isolates and characterizes novel Clostridium XIVa strains from the murine gut, revealing genomic diversity driven by mobile genetic element acquisition and expanded biosynthetic potential.

An intact S-layer is advantageous to Clostridioides difficile within the host.

This paper shows that an intact S-layer in Clostridioides difficile enhances disease severity by analyzing revertants of an S-layer-null strain and their gene expression differences.

Inhibition of proline tyrosine kinase 2 (Pyk2) phosphorylation during adherent-invasive Escherichia coli infection inhibits intra-macrophage replication and inflammatory cytokine release

This study shows that inhibiting Pyk2 reduces AIEC replication in macrophages and inflammatory cytokine release, suggesting a potential therapeutic target for Crohn's Disease.

Microbiome-derived metabolites reproduce the mitochondrial dysfunction and decreased insulin sensitivity observed in type 2 diabetes

The paper identifies two microbiome-derived metabolites, 3M-4-TMAB and 4-TMAP, that induce mitochondrial dysfunction and reduced insulin sensitivity in human liver cells, linking gut microbiota to type 2 diabetes.

Monocytes mediate Salmonella Typhimurium-induced tumour growth inhibition

This study shows that Salmonella Typhimurium SL7207 inhibits melanoma growth by recruiting pro-inflammatory monocytes, and blocking these monocytes reverses the anti-tumor effect.

Propionic acid promotes the virulent phenotype of Crohns disease-associated adherent-invasive Escherichia coli

This study shows that propionic acid exposure increases virulence in adherent-invasive Escherichia coli, leading to higher persistence in mice and altered gene expression.