H. Hulme

Genomic diversity of novel strains of mammalian gut microbiome derived Clostridium XIVa strains is driven by mobile genetic element acquisition

The paper isolates and characterizes novel Clostridium XIVa strains from the murine gut, revealing genomic diversity driven by mobile genetic element acquisition and expanded biosynthetic potential.

Defining the spatial distribution of extracellular adenosine revealed a myeloid-dependent immunosuppressive microenvironment in pancreatic ductal adenocarcinoma

This study shows that extracellular adenosine promotes an immunosuppressive microenvironment in PDAC by enhancing myeloid cell infiltration and resistance to immunotherapy, and that blocking adenosine pathway components improves therapeutic outcomes.

Microbiome-derived metabolites reproduce the mitochondrial dysfunction and decreased insulin sensitivity observed in type 2 diabetes

The paper identifies two microbiome-derived metabolites, 3M-4-TMAB and 4-TMAP, that induce mitochondrial dysfunction and reduced insulin sensitivity in human liver cells, linking gut microbiota to type 2 diabetes.

Monocytes mediate Salmonella Typhimurium-induced tumour growth inhibition

This study shows that Salmonella Typhimurium SL7207 inhibits melanoma growth by recruiting pro-inflammatory monocytes, and blocking these monocytes reverses the anti-tumor effect.

Mapping the influence of the gut microbiota on small molecules in the brain through mass spectrometry imaging

This study uses mass spectrometry imaging to map microbial and host metabolites in the gut and brain of mice, finding altered metabolites in germ-free animals but not after antibiotic treatment.