KRAS allelic imbalance drives tumour initiation yet suppresses metastasis in colorectal cancer in vivo
A. K. Najumudeen, S. K. Fey, L. M. Millet, C. A. Ford, K. Gilroy, N. Gunduz, R. A. Ridgway, E. Anderson, D. Strathdee, W. Clark, C. Nixon, J. P. Morton, A. D. Campbell, O. J. Sansom
This study shows that wild-type KRAS suppresses tumour growth and metastasis in KRAS mutant colorectal cancer while enhancing resistance to MEK inhibition.
bioRxiv · Aug 29, 2023 · PreprintCancer Biology