Author

R. A. Ridgway

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 5 Research Focus:cancer & tumor microenvironment· 4 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

O. J. Sansom· 5 shared K. Gilroy· 4 shared A. D. Campbell· 3 shared C. Nixon· 3 shared D. M. Gay· 3 shared N. Vlahov· 3 shared A. K. Najumudeen· 2 shared C. A. Ford· 2 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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5 shared papersCancer Biology

O. J. Sansom

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5 papers

Recent·Most cited

eIF4A1 is essential for reprogramming the translational landscape of Wnt-driven colorectal cancers

J. A. Waldron, G. Kanellos, R. C. L. Smith, J. R. P. Knight, J. Munro, C. Alexandrou, N. Vlahov, L. Pardo-Fernandez, M. Moore, S. L. Gillen, D. Strathdee, D. Stevenson, F. C. Warrander, K. Gilroy, C. Nixon, , O. J. Sansom

This study shows eIF4A1 is critical for supporting translational demands in Wnt-driven colorectal cancers, while eIF4A2 loss accelerates tumourigenesis, and eFT226 inhibits eIF4A1 function in these models.

bioRxiv · Nov 10, 2023 · PreprintCancer Biology

KRAS allelic imbalance drives tumour initiation yet suppresses metastasis in colorectal cancer in vivo

A. K. Najumudeen, S. K. Fey, L. M. Millet, C. A. Ford, K. Gilroy, N. Gunduz, R. A. Ridgway, E. Anderson, D. Strathdee, W. Clark, C. Nixon, J. P. Morton, A. D. Campbell, O. J. Sansom

This study shows that wild-type KRAS suppresses tumour growth and metastasis in KRAS mutant colorectal cancer while enhancing resistance to MEK inhibition.

bioRxiv · Aug 29, 2023 · PreprintCancer Biology

Metabolic profiling stratifies colorectal cancer and reveals adenosylhomocysteinase as a therapeutic target

J. Vande Voorde, A. K. Najumudeen, R. T. Steven, C. J. Nikula, A. Dexter, L. B. Zeiger, E. A. Elia, A. Nassif, A. Gonzalez-Fernandez, T. Murta, M. Gillespie, C. A. Ford, T. R. M. Lannagan, N. Vlahov, R. A. Ridgway, , O. J. Sansom

This study uses metabolomics to stratify colorectal cancer tissues and identifies adenosylhomocysteinase as a potential therapeutic target.

bioRxiv · Mar 12, 2023Cancer Biology

β-catenin obstructs γδ T cell immunosurveillance in colon cancer through loss of BTNL expression

T. Suzuki, A. Kilbey, R. A. Ridgway, H. Hayman, R. Byrne, N. Casa Rodriguez, A. Georgakopoulou, L. Chen, M. Verzi, D. M. Gay, E. G. Vzquez, H. L. Belnoue-Davis, K. Gilroy, A. H. Kostner, C. Kersten, , S. B. Coffelt

This study shows that β-catenin signaling in colon cancer cells reduces BTNL expression, impairing γδ T cell immunosurveillance and promoting tumor progression.

bioRxiv · Jun 10, 2022 · PreprintCancer Biology

Rpl24Bst mutation suppresses colorectal cancer by promoting eEF2 phosphorylation via eEF2K

J. R. Knight, N. Vlahov, D. M. Gay, R. A. Ridgway, L. Faller, C. Proud, G. R. Mallucci, T. von der Haar, C. M. Smales, A. E. Willis, O. J. Sansom

The paper shows that Rpl24Bst mutation suppresses colorectal cancer by enhancing eEF2 phosphorylation through eEF2K, reducing protein synthesis and tumorigenesis.

bioRxiv · May 5, 2021Cancer Biology