Loss of FOXP3 function causes expansion of two pools of autoreactive T cells in patients with IPEX syndrome.
S. Borna, E. Lee, U. Lakshmanan, M. Mavers, M. Narula, A. Ramachandran, J. Baker, J. Schulze, S. Olek, L. Marois, Y. Gernez, M. Bhatia, A. Bertaina, M. G. Roncarolo, E. Meffre, R. Bacchetta
FOXP3 mutations in humans lead to expansion of autoreactive T cells from both effector and regulatory T cells that gain effector function.
bioRxiv · Jul 10, 2022Immunology