Author

R. Bacchetta

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 2 Assay:scRNA-seq· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

M. G. Roncarolo· 3 shared A.-M. Cepika· 2 shared B. C. Thomas· 2 shared C. Waichler· 2 shared M. Narula· 2 shared P. P. Chen· 2 shared R. A. Freeborn· 2 shared A. Bertaina· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersImmunology

M. G. Roncarolo

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Epigenetic signature and key transcriptional regulators of human antigen-specific type 1 regulatory T cells

A.-M. Cepika, L. Amaya, C. Waichler, M. Narula, M. M. Mantilla, B. C. Thomas, P. P. Chen, R. A. Freeborn, M. Pavel-Dinu, J. Nideffer, M. Porteus, R. Bacchetta, F. Mueller, W. J. Greenleaf, H. Y. Chang, M. G. Roncarolo

This study identifies the epigenetic signature and key transcription factors regulating human antigen-specific Tr1 cells, revealing their unique biology and potential for therapeutic applications.

bioRxiv · Mar 7, 2024 · PreprintImmunology

AML/T cell interactomics uncover correlates of patient outcomes and the key role of ICAM1 in T cell killing of AML

E. C. Sayitoglu, B. A. Luca, A. P. Boss, B. C. Thomas, R. A. Freeborn, M. J. Uyeda, P. P. Chen, Y. Nakauchi, C. Waichler, N. J. Lacayo, R. Bacchetta, R. Majeti, A. J. Gentles, A.-M. Cepika, M. G. Roncarolo

The paper identifies ICAM1 as a key factor in T cell killing of AML by analyzing transcriptional programs in AML and T cell interactions.

bioRxiv · Sep 21, 2023Immunology

Loss of FOXP3 function causes expansion of two pools of autoreactive T cells in patients with IPEX syndrome.

S. Borna, E. Lee, U. Lakshmanan, M. Mavers, M. Narula, A. Ramachandran, J. Baker, J. Schulze, S. Olek, L. Marois, Y. Gernez, M. Bhatia, A. Bertaina, M. G. Roncarolo, E. Meffre, R. Bacchetta

FOXP3 mutations in humans lead to expansion of autoreactive T cells from both effector and regulatory T cells that gain effector function.

bioRxiv · Jul 10, 2022Immunology

Lung organoids and microplastic fibers: a new exposure model for emerging contaminants

A. S. Winkler, N. Santo, L. Madasci, A. Cherubini, F. Rusconi, L. Rosso, P. Tremolada, L. Lazzari, R. Bacchetta

The paper establishes an in vitro lung organoid model to study the effects of airborne microplastic fibers and finds they do not cause inflammation or oxidative stress but are incorporated into organoids.

bioRxiv · Mar 7, 2021 · PreprintMolecular Biology