Chronological lifespan extension and nucleotide salvage inhibition in yeast by isonicotinamide supplementation
A. Kalita, C. T. Letai, E. E. Hesles, L. N. Power, S. Mishra, S. Saha, M. Dinda, D. Wang, P. K. Singh, J. S. Smith
This study shows that isonicotinamide (INAM) extends yeast chronological lifespan by inhibiting nucleotide salvage pathways, leading to NAD+ accumulation and a hormetic stress response.
bioRxiv · Jul 11, 2021Biochemistry