Author

L. O. Penalva

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 4 Research Focus:differential expression· 4 Organism:human· 4 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Research Focus:cell-cell communication· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

G. D. A. Guardia· 2 shared M. Qiao· 2 shared P. A. F. Galante· 2 shared A. D. Smith· 1 shared A. Gromovsky· 1 shared A. Knudsen· 1 shared A. Savio· 1 shared B. Kristensen· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersCancer Biology

G. D. A. Guardia

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4 papers

Recent·Most cited

The paralogues MAGOH and MAGOHB are oncogenic factors in high-grade gliomas and safeguard the splicing of cell division and cell cycle genes

R. A. S. Barreiro, G. D. A. Guardia, F. M. Meliso, X. Lei, A. Savio, M. Fellermeyer, H. B. Conceicao, R. L. V. Mercuri, T. Landry, M. Qiao, L. Blazquez, J. Ule, L. O. Penalva, P. A. F. Galante

This study identifies MAGOH and MAGOHB as oncogenic factors in high-grade gliomas that safeguard splicing of cell division and cell cycle genes, with high expression linked to poor prognosis.

RNA Biology · Dec 31, 2023Peer-reviewedCancer Biology

Unveiling the role of SRY in male-biased cancers: Insights into the molecular basis of sex disparities in high-grade glioma and melanoma

G. D. A. Guardia, R. L. Batista, L. O. Penalva, P. A. F. Galante

The paper investigates SRY gene expression in high-grade glioma and melanoma, finding higher SRY expression correlates with worse prognosis in men and links to altered gene expression related to cell growth and tumor suppression.

bioRxiv · Jul 14, 2023 · PreprintCancer Biology

Altered lipid metabolism marks glioblastoma stem and non-stem cells in separate tumor niches

S. Shakya, A. Gromovsky, J. Hale, A. Knudsen, B. Prager, L. Wallace, L. O. Penalva, P. Ivanova, H. A. Brown, B. Kristensen, J. Rich, J. Lathia, J. M. Brown, C. G. Hubert

This study identifies distinct lipid metabolism patterns in glioblastoma stem and non-stem cells across different tumor microenvironments, highlighting potential therapeutic targets.

bioRxiv · Sep 20, 2020Cancer Biology

Integrated analyses of early responses to radiation in glioblastoma identify new alterations in RNA processing and candidate target genes to improve treatment outcomes

S. Choudhary, S. C. Burns, H. Mirsafian, W. Li, D. T. Vo, M. Qiao, A. D. Smith, L. O. Penalva

The paper identifies new RNA processing alterations and candidate target genes in glioblastoma cells after radiation exposure, suggesting potential strategies to improve treatment outcomes.

bioRxiv · Dec 5, 2019 · PreprintCancer Biology