J. M. Brown

Assessing the Adequacy of Morphological Models used in Palaeobiology

The paper assesses the adequacy of morphological models in phylogenetics using posterior predictive simulations and finds that current Mk model variations perform adequately but no single model is universally best.

Tumor cell-derived spermidine promotes a pro-tumorigenic immune microenvironment in glioblastoma via CD8+ T cell inhibition

This study shows that spermidine, a metabolite from glioblastoma cells, suppresses CD8+ T cell function, promoting tumor growth and poor patient outcomes.

Loss of Carnitine Palmitoyltransferase 1a Reduces Docosahexaenoic Acid-Containing Phospholipids and Drives Sexually Dimorphic Liver Disease in Mice

This study shows that liver-specific deletion of CPT1a in mice leads to reduced DHA-containing phospholipids and sexually dimorphic liver disease, with females showing more severe effects.

TLR2 Regulates Hair Follicle Cycle and Regeneration via BMP Signaling.

This study shows TLR2 regulates hair follicle cycles and regeneration through BMP signaling, with reduced TLR2 and its ligand linked to hair loss in aging and obesity.

Strain dropouts reveal interactions that govern the metabolic output of the gut microbiome

The paper investigates how strain dropouts in the gut microbiome affect community metabolism and host physiology, finding that functionally redundant strains can have significant impacts outside their niche.

Safety and biodistribution of NanoligomersTM targeting SARS-CoV-2 genome for treatment of COVID-19

This paper evaluates the safety and biodistribution of a novel Nanoligomer targeting SARS-CoV-2 in mice, showing it is safe, nontoxic, and effectively distributed throughout the body.

Membrane-Bound O-Acyltransferase 7 (MBOAT7)-Driven Lysophosphatidylinositol (LPI) Acylation in Adipocytes Contributes to Systemic Glucose Homeostasis

This study shows that MBOAT7 in adipocytes regulates PI homeostasis and contributes to hyperinsulinemia and systemic insulin resistance in mice.

Prime-pull immunization of mice with a BcfA-adjuvanted vaccine elicits mucosal immunity and prevents SARS CoV-2 infection and pathology

The MIF SNP rs755622 is a germline determinant of tumor immune activation in Glioblastoma

The paper identifies a germline SNP, rs755622, associated with increased leukocyte infiltration in glioblastoma and links it to lactotransferrin expression as a potential biomarker for immune activation.

Gut Microbial Trimethylamine is Elevated in Alcohol-Associated Hepatitis and Contributes to Ethanol-Induced Liver Injury in Mice

This study shows elevated trimethylamine (TMA) in alcohol-associated hepatitis patients and demonstrates that inhibiting gut microbial TMA production protects mice from ethanol-induced liver injury.

A gut microbial metabolite of dietary polyphenols reverses obesity-driven hepatic steatosis

Identification of essential genes for Escherichia coli aryl polyene biosynthesis and function in biofilm formation

This study identifies essential genes for aryl polyene biosynthesis in E. coli and shows APEs enhance biofilm formation and oxidative stress resistance.

Resolving the structure of phage-bacteria interactions in the context of natural diversity

The paper studies phage-bacteria interactions in marine environments, finding sparse killing and common recombination among phages.

Robust integrated intracellular organization of the human iPS cell: where, how much, and how variable

The paper establishes quantitative rules for the locations, amounts, and variation of 25 cellular structures in human iPSCs using high-resolution imaging and analysis.

Gut Microbe-Targeted Choline Trimethylamine Lyase Inhibition Improves Obesity Via Rewiring of Host Circadian Rhythms

The paper shows that inhibiting gut microbial choline TMA-lyase reduces obesity in mice by altering microbiome composition and host circadian rhythms.

A Novel Surgical Method for Continuous Intra-Portal Infusion of Gut Microbial Metabolites in Mice

This paper introduces a novel surgical method for continuous portal vein infusion of gut microbial metabolites in mice, demonstrating its effectiveness in altering plasma and hepatic metabolite levels and gene expression.

Altered lipid metabolism marks glioblastoma stem and non-stem cells in separate tumor niches

This study identifies distinct lipid metabolism patterns in glioblastoma stem and non-stem cells across different tumor microenvironments, highlighting potential therapeutic targets.

Gene exchange networks define species-like units in marine prokaryotes

The paper identifies gene exchange networks in marine prokaryotes, showing they form broader evolutionary units than traditional species definitions.

Disruption of the gut microbiota attenuates epithelial ovarian cancer sensitivity to cisplatin therapy

This study shows that antibiotic treatment disrupts the gut microbiome, leading to increased resistance to cisplatin in ovarian cancer models.

Ancestral absence of electron transport chains in Patescibacteria and DPANN

The paper investigates Patescibacteria and DPANN, finding they lack electron transport chains and rely on fermentation, suggesting ancestral adaptations to symbiotic lifestyles.

Cancer Stem Cell Enrichment and Metabolic Substrate Adaptability are Driven by Hydrogen Sulfide Suppression in Glioblastoma

A high-fat diet accelerates glioblastoma by inhibiting hydrogen sulfide production, leading to cancer stem cell enrichment and reduced treatment response.

SR-B1 uptake of HDL promotes prostate cancer proliferation and tumor progression

Membrane-Bound O-Acyltransferase 7 (MBOAT7) is a Key Regulator of Glycolysis in Clear Cell Renal Carcinoma.

This study shows MBOAT7 regulates glycolysis in ccRCC by reducing glycolytic gene expression, intermediates, and respiration, and improving survival in xenograft models.

Cholangiocarcinoma presents a distinct myeloid-derived suppressor cell signature compared to other hepatobiliary cancers

The paper identifies a distinct myeloid-derived suppressor cell (MDSC) signature in cholangiocarcinoma (CCA) compared to other hepatobiliary cancers, linking MDSC levels to disease outcomes and potential therapeutic targets.

MBOAT7-Driven Phosphatidylinositol Remodeling Promotes the Progression of Clear Cell Renal Cell Carcinoma.

This study identifies MBOAT7-driven phosphatidylinositol remodeling as a driver of clear cell renal cell carcinoma progression and highlights MBOAT7 as a potential therapeutic target.

Differences in proteome response to cold acclimation in Zoysia japonica cultivars with different levels of freeze tolerance

This study compares proteome responses to cold acclimation in two Zoysia japonica cultivars with different freeze tolerance, identifying differentially expressed proteins involved in cold response mechanisms.

Dispersal limitation and thermodynamic constraints govern spatial structure of permafrost microbial communities

This study identifies dispersal limitation and thermodynamic constraints as key factors shaping permafrost microbial community structure, distinct from non-permafrost soils.

A tissue-specific self-interacting chromatin domain forms independently of enhancer-promoter interactions

The paper shows that an erythroid-specific self-interacting chromatin domain forms before gene activation and does not depend on enhancer-promoter interactions.

Unexpected variation across mitochondrial gene trees and evidence for systematic error: How much gene tree variation is biological?

The paper estimates gene tree discordance caused by systematic error using mitochondrial genomes and finds it comparable to variation attributed to biological causes.