Author

C. G. Hubert

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Approach:experimental assay· 3 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 1 Approach:deep learning· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

D. J. Silver· 2 shared E. E. Mulkearns-Hubert· 2 shared J. Lathia· 2 shared L. Wallace· 2 shared S. Shakya· 2 shared A. Gromovsky· 1 shared A. Kashyap· 1 shared A. Knudsen· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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2 shared papersCancer Biology

D. J. Silver

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Author profile →

4 papers

Recent·Most cited

Tumor cell-intrinsic HFE drives glioblastoma growth

K. M. Troike, D. J. Silver, P. K. Ghosh, E. E. Mulkearns-Hubert, C. G. Hubert, J. R. Connor, P. L. Fox, B. W. Kristensen, J. Lathia

This study shows that HFE promotes glioblastoma growth by regulating iron homeostasis and oxidative stress, with HFE loss inducing apoptosis and extending survival.

bioRxiv · Apr 13, 2022 · PreprintCancer Biology

How to use transcriptomic data for game-theoretic modeling of treatment-induced resistance in cancer cells? A case study in patient-derived glioblastoma organoids

L. Spekking, C. Lokh, W. Jung, M. Verduin, S. Azimi, C. G. Hubert, M. Vooijs, R. Cavill, K. Stankova

This paper uses transcriptomic data from glioblastoma organoids to predict evolutionary responses to irradiation using game-theoretic models, finding hypoxia drives short-term resistance while supervised methods best estimate evolutionary dynamics.

bioRxiv · Jan 26, 2022 · PreprintCancer Biology

WDR5 represents a therapeutically exploitable target for cancer stem cells in glioblastoma

K. Mitchell, S. Shakya, S. Arora, S. A. Sprowls, D. J. Silver, C. M. Goins, L. Wallace, G. Roversi, R. Schafer, K. Kay, T. E. Miller, A. Lauko, A. Kashyap, J. D. Kass, E. E. Mulkearns-Hubert, , J. D. Lathia

This study identifies WDR5 as an essential epigenetic regulator in therapy-resistant glioblastoma cancer stem cells and shows that WDR5 inhibitors disrupt CSC maintenance and tumor growth.

bioRxiv · Sep 20, 2021Cancer Biology

Altered lipid metabolism marks glioblastoma stem and non-stem cells in separate tumor niches

S. Shakya, A. Gromovsky, J. Hale, A. Knudsen, B. Prager, L. Wallace, L. O. Penalva, P. Ivanova, H. A. Brown, B. Kristensen, J. Rich, J. Lathia, J. M. Brown, C. G. Hubert

This study identifies distinct lipid metabolism patterns in glioblastoma stem and non-stem cells across different tumor microenvironments, highlighting potential therapeutic targets.

bioRxiv · Sep 20, 2020Cancer Biology