S. Choudhary

Evolved and plastic gene expression in adaptation to a novel niche

The paper investigates evolved and plastic gene expression differences in adaptation to a novel niche using peacock flies, finding ecotype-specific gene expression changes and an inversion linked to differential expression.

Tick bite-induced Alpha-Gal Syndrome and Immunologic Responses in an Alpha-Gal Deficient Murine Model

This study investigates how different tick species influence the development of Alpha-Gal Syndrome in a genetically modified mouse model by analyzing immune responses and gene expression.

Characterization of the pearl millet cultivation environments in India: status and perspectives enabled by expanded data analytics and digital tools

The paper characterizes pearl millet cultivation in India using new data and models, finding regional growth and decline trends and climate impacts.

Selective estrogen receptor modulators limit alphavirus infection by targeting the viral capping enzyme nsP1

This study shows that SERMs inhibit alphavirus infection by targeting the viral capping enzyme nsP1, with antiviral effects observed in cell culture and mice.

BNT162b vaccines are immunogenic and protect non-human primates against SARS-CoV-2

This paper evaluates two BNT162b vaccine candidates in non-human primates, showing they are immunogenic and protect against SARS-CoV-2 infection.

A small molecule that binds an RNA repeat expansion stimulates its decay via the exosome complex

A small molecule binds an RNA repeat expansion, reversing disease defects in DM1 and FECD by either disabling gain-of-function or stimulating exosome-mediated decay.

Presence of polyadenylated 3' tail in RNA of Pepper mild mottle virus allows the Oligo(dT)18 in Priming cDNA Synthesis of its genomic RNA template

This study shows that Pepper mild mottle virus (PMMoV) genomic RNA has polyadenylated 3' tails, allowing oligo(dT)18 priming despite lacking poly(A) tails in its 3' UTR.

Integrated analyses of early responses to radiation in glioblastoma identify new alterations in RNA processing and candidate target genes to improve treatment outcomes

The paper identifies new RNA processing alterations and candidate target genes in glioblastoma cells after radiation exposure, suggesting potential strategies to improve treatment outcomes.

Mapping person-to-person variation in viral mutations that escape polyclonal serum targeting influenza hemagglutinin

The paper maps how amino-acid mutations in influenza's hemagglutinin affect neutralization by polyclonal human sera, showing individual variation in escape mutations not observed in ferrets.

Determining the link between alpha-gal-containing antigens in North American ticks and red meat allergy

This study identifies the presence of alpha-gal in the salivary glands of two tick species and links it to red meat allergy through IgE antibody responses.

Expanding primary cells from mucoepidermoid and other salivary gland neoplasms for genetic and chemosensitivity testing

This study establishes a method to expand primary cells from salivary gland neoplasms for genetic and chemosensitivity testing, identifying therapeutic targets and resistance mechanisms.