Author

L. S. Brown

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

E. G. Govorunova· 3 shared H. Li· 3 shared J. L. Spudich· 3 shared O. A. Sineshchekov· 3 shared Y. Wang· 3 shared A. J. Fortune· 1 shared A. L. Cook· 1 shared A. Palmateer· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersBiochemistry

E. G. Govorunova

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Induced pluripotent stem cell derived pericytes respond to endogenous mediators of proliferation and contractility

N. E. King, J.-M. Courtney, L. S. Brown, A. J. Fortune, N. B. Blackburn, J. L. Fletcher, J. M. Cashion, J. Talbot, A. Pebay, A. W. Hewitt, G. P. Morris, K. M. Young, A. L. Cook, B. A. Sutherland

This study compares iPSC-derived pericytes to primary human brain vascular pericytes, showing they express pericyte markers and respond to growth factors and vasoactive mediators, though with gene expression differences.

bioRxiv · Sep 29, 2023Cell Biology

Kalium rhodopsins: Natural light-gated potassium channels

E. G. Govorunova, Y. Gou, O. A. Sineshchekov, H. Li, Y. Wang, L. S. Brown, M. Xue, J. L. Spudich

The paper identifies KCRs, light-gated potassium channels from a fungus-like protist, which are highly selective and fast-acting, showing potential for optogenetic control of potassium gradients in neurological and cardiac diseases.

bioRxiv · Sep 17, 2021 · PreprintBiochemistry

Cation and anion channelrhodopsins: Sequence motifs and taxonomic distribution

E. G. Govorunova, O. A. Sineshchekov, H. Li, Y. Wang, L. S. Brown, A. Palmateer, M. Melkonian, S. Cheng, E. Carpenter, J. Patterson, G. K.-S. Wong, J. L. Spudich

The paper identifies and characterizes sequence motifs and ion selectivity mechanisms in channelrhodopsins from diverse algal and protist species using electrophysiological analysis and genomic data.

bioRxiv · Mar 23, 2021Biochemistry

RubyACRs, non-algal anion channelrhodopsins with highly red-shifted absorption

E. G. Govorunova, O. A. Sineshchekov, H. Li, Y. Wang, L. S. Brown, J. L. Spudich

The paper identifies and characterizes two new families of anion channelrhodopsins (ACRs), including RubyACRs with highly red-shifted absorption spectra, expanding optogenetic tools for neural inhibition.

bioRxiv · Apr 15, 2020Biochemistry