Author

A. W. Hewitt

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Cell Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:cell type annotation· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 1 Assay:CRISPR screen· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. Pebay· 3 shared A. L. Cook· 2 shared G.-S. Liu· 2 shared J. Chen· 2 shared J.-H. Wang· 2 shared K. M. Young· 2 shared P.-Y. Wang· 2 shared R. C.-B. Wong· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersCell Biology

A. Pebay

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Induced pluripotent stem cell derived pericytes respond to endogenous mediators of proliferation and contractility

N. E. King, J.-M. Courtney, L. S. Brown, A. J. Fortune, N. B. Blackburn, J. L. Fletcher, J. M. Cashion, J. Talbot, A. Pebay, A. W. Hewitt, G. P. Morris, K. M. Young, A. L. Cook, B. A. Sutherland

This study compares iPSC-derived pericytes to primary human brain vascular pericytes, showing they express pericyte markers and respond to growth factors and vasoactive mediators, though with gene expression differences.

bioRxiv · Sep 29, 2023Cell Biology

TAK1 blockade as a therapy for retinal neovascularization

F.-L. Lin, J.-H. Wang, J. Chen, L. Zhu, Y.-F. Chuang, L. Tu, C. Ma, S. Lama, D. Ling, R. C.-B. Wong, A. W. Hewitt, C.-L. Tseng, B. V. Bui, P. van Wijngaarden, G. J. Dusting, , G.-S. Liu

This study investigates TAK1's role in retinal neovascularization and shows that inhibiting TAK1 reduces aberrant angiogenesis in a rat model.

bioRxiv · Jan 29, 2021Biochemistry

Combinatorial approach of binary colloidal crystals (BCCs) and CRISPR activation to improve induced pluripotent stem cell differentiation into neurons

D. Urrutia-Cabrera, R. H.-C. Liou, J. Lin, K. Liu, S. S.-C. Hung, A. W. Hewitt, P.-Y. Wang, R. C.-B. Wong

This study combines CRISPR activation and binary colloidal crystals to enhance the rapid differentiation of human iPSCs into neurons.

bioRxiv · Dec 21, 2020Bioengineering

Evolving Transcriptomic Signature of Human Pluripotent Stem Cell-Derived Retinal Pigment Epithelium Cells With Age

G. E. Lidgerwood, A. Senabouth, C. J. A. Smith-Anttila, V. Gnanasambandapillai, D. C. Kaczorowski, D. Amann-Zalcenstein, E. L. Fletcher, S. H. Naik, A. W. Hewitt, J. Powell, A. Pebay

This study characterizes the transcriptomic changes in hPSC-derived RPE cells over time in culture, showing a maturing transcriptional profile that resembles native RPE.

bioRxiv · Jul 26, 2020Cell Biology

Comparison of CRISPR/Cas endonucleases for in vivo retinal gene editing.

F. Li, K. Wing, J.-H. Wang, C. D. Luu, J. A. Bender, J. Chen, Q. Wang, Q. Lu, M. T. N. T. Tran, K. M. Young, R. C. Wong, A. Pebay, A. L. Cook, S. S. Hung, G.-S. Liu, A. W. Hewitt

This study compares CRISPR/Cas endonucleases for in vivo retinal gene editing and finds SpCas9 delivered via AAV7m8 achieves the highest knockout efficacy.

bioRxiv · Jun 9, 2020Bioengineering