Mitochondrial replacement in an iPSC model of Leber Hereditary Optic Neuropathy.
R. Wong, S. Y. Lim, S. S. Hung, S. Jackson, S. Khan, N. J. Van Bergen, E. De Smit, H. H. Liang, L. S. Kearns, L. Clarke, D. A. Mackey, A. Hewitt, I. A. Trounce, A. Pebay
The paper uses cybrid technology to replace mtDNA mutations in iPSCs derived from LHON patients, showing reduced RGC death in corrected cells.
bioRxiv · Mar 26, 2017Cell Biology