R. Wong

Behavioral adaptation to changing energy constraints via altered frequency of movement selection

The paper shows larval zebrafish adjust movement frequency to minimize energy use as they grow, even in altered fluid environments.

Genome-wide screen identifies new set of genes for improved heterologous laccase expression in Saccharomyces cerevisiae

The paper screens yeast mutants to identify genes that enhance recombinant laccase secretion, finding that vesicle trafficking and chaperone proteins are critical for improved protein production.

Peripheral detection of viruses shapes brain immunity and behavior in zebrafish

This study shows that viral detection by olfactory sensory neurons in zebrafish triggers neuroimmune responses and behavioral changes through PACAP signaling in the olfactory bulb.

T-cell cellular stress and reticulocyte signatures, but not loss of naive T lymphocytes, characterize severe COVID-19 in older adults

The paper identifies T-cell stress and reticulocyte signatures as markers of severe COVID-19 in older adults, while showing naive T-cell decline is age-related, not disease-specific.

Non-canonical Telomerase Reverse Transcriptase Controls Osteogenic Reprogramming of Aortic Valve Cells Through STAT5

This study identifies TERT's non-canonical role in osteogenic reprogramming of aortic valve cells through STAT5, offering a potential therapeutic target for calcific aortic valve disease.

Complete Protection of Nasal and Lung Airways Against SARS-CoV-2 Challenge by Antibody Plus Th1 Dominant N- and S-Specific T-Cell Responses to Subcutaneous Prime and Thermally-Stable Oral Boost Bivalent hAd5 Vaccination in an NHP Study

hAd5 spike + nucleocapsid SC prime/oral boost vaccine elicits humoral and T-cell responses and protects rhesus macaques from SARS-CoV-2 challenge.

ZBTB38 is dispensable for hematopoiesis and antibody responses.

This study shows ZBTB38 is not essential for hematopoiesis or antibody responses, as its deletion in mice does not impair germinal center B cells or immunization outcomes.

MAVS regulates the quality of the antibody response to West-Nile Virus

This study shows that MAVS, an RLR signaling adaptor, is critical for the quality of the antibody response to WNV, as MAVS-deficient mice produced low-affinity IgM antibodies despite normal antigen levels.

Beyond Conventional Models: Recreating the Initiation, Evolution, and Genome of GBM

This study develops a mouse model of glioblastoma (GBM) that replicates its genomic landscape and early stages, enabling research into prevention and treatment strategies.

The Molecular and Microbial Microenvironments in Chronically Diseased Lungs

The paper generates 3D maps of microbiomes and metabolomes in cystic fibrosis lungs, revealing personalized and regiospecific chemical environments and microbial interactions.

β1 integrin is a sensor of blood flow direction

This study identifies β1 integrin as a sensor for blood flow direction in endothelial cells, showing it is activated by unidirectional but not bidirectional shear stress.

Mitochondrial replacement in an iPSC model of Leber Hereditary Optic Neuropathy.

The paper uses cybrid technology to replace mtDNA mutations in iPSCs derived from LHON patients, showing reduced RGC death in corrected cells.