Shifting a Cellular Metabolic Landscape Identifies a Refractory Environment for Flavivirus Replication
R. C. Gullberg, N. Chotiwan, M. N. Islam, L. St Clair, E. Lian, T. J. Edwards, S. Khadka, C. Teng, B. Graham, K. Krieger, A. Hopf-Jannasch, D. J. LaCount, J. T. Belisle, R. J. Kuhn, R. Perera
The paper identifies a refractory metabolic environment induced by fatty acid biosynthesis inhibition that limits flavivirus replication and shows that combining this with nucleotide synthesis pathway inhibition significantly reduces viral infectivity.
bioRxiv · Feb 21, 2022 · PreprintMicrobiology