Author

E. Lian

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:Arabidopsis· 1 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

R. Perera· 4 shared G. Ramirez· 3 shared N. Chotiwan· 3 shared R. C. Gullberg· 2 shared A. Camacho-Magallanes· 1 shared A. Hopf-Jannasch· 1 shared A. Nag· 1 shared A. Pietrobon· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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4 shared papersMicrobiology

R. Perera

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Shifting a Cellular Metabolic Landscape Identifies a Refractory Environment for Flavivirus Replication

R. C. Gullberg, N. Chotiwan, M. N. Islam, L. St Clair, E. Lian, T. J. Edwards, S. Khadka, C. Teng, B. Graham, K. Krieger, A. Hopf-Jannasch, D. J. LaCount, J. T. Belisle, R. J. Kuhn, R. Perera

The paper identifies a refractory metabolic environment induced by fatty acid biosynthesis inhibition that limits flavivirus replication and shows that combining this with nucleotide synthesis pathway inhibition significantly reduces viral infectivity.

bioRxiv · Feb 21, 2022 · PreprintMicrobiology

Expression of fatty acid synthase genes and their role in development and arboviral infection of Aedes aegypti

N. Chotiwan, C. A. Brito-Sierra, G. Ramirez, E. Lian, C. A. Hill, R. Perera

This study identifies and characterizes FAS genes in Aedes aegypti, showing AaFAS1's role in dengue virus infection and transmission.

bioRxiv · Feb 14, 2022Microbiology

Acyl-CoA Thioesterases; a rheostat that controls activated fatty acids modulates dengue virus serotype 2 replication

L. A. St Clair, S. A. Mills, E. Lian, P. S. Soma, A. Nag, C. Montgomery, G. Ramirez, N. Chotiwan, R. C. Gullberg, R. Perera

This study investigates the role of acyl-CoA thioesterases (ACOTs) in modulating dengue virus serotype 2 replication, showing that their loss of function affects viral replication and infectious particle release.

bioRxiv · Dec 12, 2021Microbiology

Three-dimensional drug screen identifies HDAC inhibitors as therapeutic agents in mTORC1-driven lymphangioleiomyomatosis

A. Pietrobon, J. Yockell-Lelievre, N. Melong, L. J. Smith, S. P. Delaney, N. Azzam, C. Xue, N. Merwin, E. Lian, A. Camacho-Magallanes, C. Dore, G. Musso, L. M. Julian, A. S. Kristof, R. Y. Tam, , W. L. Stanford

A 3D drug screen identified HDAC inhibitors as effective against mTORC1-driven lymphangioleiomyomatosis by reducing invasion and selectively killing TSC2-/- cells.

bioRxiv · Jul 3, 2021Cell Biology

Triple Combination Nitazoxanide, Ribavirin, and Hydroxychloroquine results in the multiplicative reduction of in vitro SARS-CoV-2 viral replication

E. Lian, C. McAlister, G. Ramirez, D. N. Chernoff, G. Went, J. Hoopes, R. Perera

This study tests a triple drug combination for reducing SARS-CoV-2 replication in vitro, finding a significant multiplicative effect on virus yield and delayed cytopathic effects.

bioRxiv · Nov 25, 2020 · PreprintMicrobiology