S. Khadka

Endogenous glucocorticoids are required for normal macrophage activation and gastric Helicobacter pylori immunity

This study shows that glucocorticoids are necessary for proper macrophage activation and immune response to Helicobacter pylori in the stomach.

Comparison of gastric inflammation and metaplasia induced by Helicobacter pylori or Helicobacter felis colonization in mice

This study compares gastric inflammation and metaplasia induced by Helicobacter pylori or Helicobacter felis in mice, finding that HF causes more severe inflammation and atrophy than HP.

Mantis: high-throughput 4D imaging and analysis of the molecular and physical architecture of cells

The paper introduces Mantis, a high-throughput 4D microscope, and shrimPy, software for analyzing 4D data, to study cellular dynamics and responses to perturbations like viral infection.

Anaplerotic nutrient stress drives synergy of angiogenesis inhibitors with therapeutics targeting tumor metabolism

This study shows that angiogenesis inhibitors enhance the effectiveness of metabolic therapies in gliomas by inducing anaplerotic nutrient stress.

Genetic depletion of de novo coenzyme A biosynthesis exacerbates puromycin toxicity

The paper shows that reducing coenzyme A biosynthesis increases cancer cells' sensitivity to puromycin, a selection antibiotic used in research.

Epitranscriptomic N6-methyladenosine profile of SARS-CoV-2-infected human lung epithelial cells

This study examines how m6A modification of host cell RNAs changes during SARS-CoV-2 infection in human lung epithelial cells and identifies associated biological pathways and regulators.

Regulation of Klebsiella pneumoniae mucoidy by the bacterial tyrosine kinase Wzc

This study identifies Wzc mutations as a mechanism for increased mucoidy in K. pneumoniae without altering EPS abundance, independent of rmp status.

Shifting a Cellular Metabolic Landscape Identifies a Refractory Environment for Flavivirus Replication

The paper identifies a refractory metabolic environment induced by fatty acid biosynthesis inhibition that limits flavivirus replication and shows that combining this with nucleotide synthesis pathway inhibition significantly reduces viral infectivity.

Generation and validation of an anti-human PANK3 mouse monoclonal antibody

The paper generates and validates a mouse monoclonal antibody against human PANK3 to enable reliable detection of this enzyme in cancer cell lines.

Quantification of phosphonate drugs by 1H-31P HSQC shows that rats are better models of primate drug exposure than mice

The paper quantifies phosphonate drugs using 1H-31P HSQC NMR, showing rats provide better drug exposure models than mice for phosphonate-containing compounds.

Marburg and Ebola virus mRNA 3 untranslated regions contain negative regulators of translation that are modulated by ADAR1 editing

This study identifies ADAR1-mediated editing of filovirus 3UTRs as negative regulators of translation, showing that editing or deletion enhances translation and modulates immune responses.

Pharmacokinetics of Orally Administered GS-441524 in Dogs

This study evaluates the oral bioavailability of GS-441524 in dogs, showing sustained plasma concentrations above the EC50 for SARS-CoV-2.

Robust detection of oncometabolic aberrations by 1H-13C heteronuclear single quantum correlation in live cells and intact tumors ex-vivo

This paper demonstrates that 1H-13C HSQC NMR can detect oncometabolic aberrations in live cells and tumors without specialized equipment, improving sensitivity and resolution over traditional methods.