Author

R. J. Kuhn

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Immunology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:cryo-EM· 1 Research Focus:development & morphogenesis· 1 Assay:electronic health records· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. Egorova· 1 shared A. Hopf-Jannasch· 1 shared A. S. Miller· 1 shared B. Graham· 1 shared B. Hurst· 1 shared B. Sherry· 1 shared B. Tarbet· 1 shared C. A. Lopez· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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Curved chords = mutual co-authorship

1 shared paperPharmacology & Toxicology

A. Egorova

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Author profile →

4 papers

Recent·Most cited

Contribution of the Golgi apparatus in morphogenesis of a virus induced cytopathic vacuolar system

R. Sengupta, E. M. Mihelc, S. Angel, J. K. Lanman, R. J. Kuhn, R. V. Stahelin

The paper investigates how the Golgi apparatus transforms into cytopathic vacuoles during alphavirus infection using electron tomography and Golgi markers.

bioRxiv · Mar 14, 2022Microbiology

Shifting a Cellular Metabolic Landscape Identifies a Refractory Environment for Flavivirus Replication

R. C. Gullberg, N. Chotiwan, M. N. Islam, L. St Clair, E. Lian, T. J. Edwards, S. Khadka, C. Teng, B. Graham, K. Krieger, A. Hopf-Jannasch, D. J. LaCount, J. T. Belisle, R. J. Kuhn, R. Perera

The paper identifies a refractory metabolic environment induced by fatty acid biosynthesis inhibition that limits flavivirus replication and shows that combining this with nucleotide synthesis pathway inhibition significantly reduces viral infectivity.

bioRxiv · Feb 21, 2022 · PreprintMicrobiology

Strain dependent structural effects and in vivo efficacy of enterovirus-D68 inhibitors

T. R. Lane, J. Fu, B. Sherry, B. Tarbet, B. Hurst, O. Riabova, E. Kazakova, A. Egorova, P. Clarke, J. S. Leser, J. Frost, M. Rudy, K. Tyler, T. Klose, R. J. Kuhn, , S. Ekins

This study develops a potent EV-D68 inhibitor, 11526092, showing improved in vitro potency and in vivo efficacy compared to pleconaril, with strain-dependent structural effects observed via cryo-EM.

bioRxiv · Dec 24, 2021 · PreprintPharmacology & Toxicology

Zika virus-specific IgM elicited during pregnancy exhibits ultrapotent neutralization

T. Singh, K.-K. Hwang, A. S. Miller, R. L. Jones, C. A. Lopez, C. Giuberti, M. A. Gladden, I. Miller, H. S. Webster, J. A. Eudailey, K. Luo, T. Von Holle, R. J. Edwards, S. Valencia, K. E. Burgomaster, , M. Bonsignori

This study identifies a potent ZIKV-neutralizing IgM antibody from a pregnant woman and shows its protective efficacy in mice.

bioRxiv · Nov 23, 2021Immunology