Targeting a central feature of asthma using a cell type-selective IL-13-responsive enhancer
K. D. Koh, L. R. Bonser, W. L. Eckalbar, J. Shen, O. Yizhar-Barnea, X. Zeng, D. I. Sun, L. T. Zlock, W. E. Finkbeiner, N. Ahituv, D. J. Erle
The paper identifies cell type-selective IL-13-responsive enhancers in airway epithelial cells and demonstrates their therapeutic potential for asthma by targeting mucin production.
bioRxiv · Oct 8, 2021 · PreprintImmunology