Author

D. J. Erle

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 7 Cell Biology· 2

Signature Assays, Organisms & Methods

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Organism:human· 8 Approach:experimental assay· 7 Assay:bulk RNA-seq· 6 Research Focus:cell type annotation· 6 Research Focus:differential expression· 4 Research Focus:host-pathogen & immune response· 4 Approach:statistical model· 4 Assay:flow cytometry· 3

Frequent Co-Authors

M. F. Krummel· 5 shared P. G. Woodruff· 5 shared A. A. Rao· 3 shared A. J. Combes· 3 shared C. M. Hendrickson· 3 shared C. R. Langelier· 3 shared C. S. Calfee· 3 shared G. K. Fragiadakis· 3 shared

Activity by Year

2018-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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5 shared papersImmunology

M. F. Krummel

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Author profile →

9 papers

Recent·Most cited

Immediate myeloid depot for SARS-CoV-2 in the human lung

M. Magnen, R. You, A. A. Rao, R. T. Davis, L. Rodriguez, C. R. Simoneau, L. Hysenaj, K. H. Hu, The UCSF COMET Consortium, C. Love, P. G. Woodruff, D. J. Erle, C. M. Hendrickson, C. S. Calfee, M. A. Matthay, , M. R. Looney

The paper investigates early SARS-CoV-2 infection in human lung myeloid cells, finding rapid viral tropism, ACE2 dependence, and poor interferon induction, suggesting a myeloid depot for viral persistence.

bioRxiv · Apr 28, 2022Immunology

A conserved immune trajectory of recovery in hospitalized COVID-19 patients

T. L. H. Okholm, C. E. Burnett, I. Tenvooren, D. M. Marquez, S. Tamaki, P. M. Sandoval, The UCSF COMET Consortium, C. S. Calfee, C. M. Hendrickson, K. N. Kangelaris, C. R. Langelier, M. F. Krummel, P. G. Woodruff, D. J. Erle, K. M. Ansel, M. H. Spitzer

The paper identifies a conserved immune recovery trajectory in hospitalized COVID-19 patients through longitudinal mass cytometry analysis, linking immune processes to clinical outcomes.

bioRxiv · Mar 15, 2022 · PreprintImmunology

Targeting a central feature of asthma using a cell type-selective IL-13-responsive enhancer

K. D. Koh, L. R. Bonser, W. L. Eckalbar, J. Shen, O. Yizhar-Barnea, X. Zeng, D. I. Sun, L. T. Zlock, W. E. Finkbeiner, N. Ahituv, D. J. Erle

The paper identifies cell type-selective IL-13-responsive enhancers in airway epithelial cells and demonstrates their therapeutic potential for asthma by targeting mucin production.

bioRxiv · Oct 8, 2021 · PreprintImmunology

A Pan-Cancer Census of Dominant Tumor Immune Archetypes

A. J. Combes, B. Samad, J. Tsui, N. W. Chew, P. Yan, G. C. Reeder, D. Kushnoor, A. Shen, B. Davidson, A. J. Barczac, M. Adkisson, A. Edwards, M. Naser, K. C. Barry, T. Courau, , M. F. Krummel

The paper identifies dominant immune system archetypes across 364 tumors from 12 cancer types using flow cytometry and transcriptomic data, linking them to tumor biology classifications.

bioRxiv · Apr 26, 2021 · PreprintImmunology

Longitudinal single-cell epitope and RNA-sequencing reveals the immunological impact of type 1 interferon autoantibodies in critical COVID-19

M. G. P. van der Wijst, S. E. Vazquez, G. C. Hartoularos, P. Bastard, T. Grant, R. Bueno, D. S. Lee, J. R. Greenland, Y. Sun, R. Perez, A. Ogorodnikov, A. Ward, S. A. Mann, K. L. Lynch, C. Yun, , C. R. Langelier

The paper examines IFN-I autoantibodies in critical COVID-19 patients through longitudinal single-cell analysis, revealing suppressed ISG-I responses in myeloid cells.

bioRxiv · Mar 9, 2021 · PreprintImmunology

The type 2 asthma mediator IL-13 inhibits SARS-CoV-2 infection of bronchial epithelium

L. R. Bonser, W. L. Eckalbar, L. Rodriguez, J. Shen, K. D. Koh, L. T. Zlock, S. Christenson, P. G. Woodruff, W. E. Finkbeiner, D. J. Erle

This study shows IL-13 reduces SARS-CoV-2 infection in bronchial epithelial cells by altering gene expression and inhibiting viral replication.

bioRxiv · Feb 25, 2021Cell Biology

Global Absence and Targeting of Protective Immune States in Severe COVID-19.

A. J. Combes, T. Courau, N. F. Kuhn, K. H. Hu, A. Ray, W. S. Chen, S. J. Clearly, N. W. Chew, D. Kushnoor, G. C. Reeder, A. Shen, J. Tsui, K. J. Hiam-Galvez, P. Munoz-Sandoval, W. S. Zhu, , M. F. Krummel

The paper identifies that severe COVID-19 patients lack ISG-expressing cells and have antibodies that block their production, contrasting with mild cases.

bioRxiv · Oct 28, 2020Immunology

Flow cytometric analysis and purification of airway epithelial cell subsets

L. R. Bonser, K. D. Koh, K. Johansson, S. P. Choksi, D. Cheng, L. Liu, D. I. Sun, L. T. Zlock, W. L. Eckalbar, W. E. Finkbeiner, D. J. Erle

The paper develops flow cytometric panels to isolate human airway epithelial subsets using scRNA-seq data and cell type markers, identifying subpopulations and low-abundance transcripts in secretory cells.

bioRxiv · Apr 20, 2020Cell Biology

Detection of succinate by intestinal tuft cells triggers a type 2 innate immune circuit

M. S. Nadjsombati, J. W. McGinty, M. R. Lyons-Cohen, J. L. Pollack, G. A. Nagana Gowda, D. J. Erle, R. M. Locksley, D. Raftery, J. von Moltke

The paper identifies succinate as a ligand that activates intestinal tuft cells to initiate type 2 immune responses, linking microbial metabolism to immune sensing.

bioRxiv · Apr 29, 2018Immunology