Author

W. L. Eckalbar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Assay:bulk RNA-seq· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:cell type annotation· 2 Approach:statistical model· 2 Assay:ChIP-seq· 1 Research Focus:differential expression· 1

Frequent Co-Authors

D. J. Erle· 3 shared K. D. Koh· 3 shared L. R. Bonser· 3 shared L. T. Zlock· 3 shared W. E. Finkbeiner· 3 shared D. I. Sun· 2 shared J. Shen· 2 shared A. K. Shum· 1 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersCell Biology

D. J. Erle

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Author profile →

5 papers

Recent·Most cited

Targeting a central feature of asthma using a cell type-selective IL-13-responsive enhancer

K. D. Koh, L. R. Bonser, W. L. Eckalbar, J. Shen, O. Yizhar-Barnea, X. Zeng, D. I. Sun, L. T. Zlock, W. E. Finkbeiner, N. Ahituv, D. J. Erle

The paper identifies cell type-selective IL-13-responsive enhancers in airway epithelial cells and demonstrates their therapeutic potential for asthma by targeting mucin production.

bioRxiv · Oct 8, 2021 · PreprintImmunology

The type 2 asthma mediator IL-13 inhibits SARS-CoV-2 infection of bronchial epithelium

L. R. Bonser, W. L. Eckalbar, L. Rodriguez, J. Shen, K. D. Koh, L. T. Zlock, S. Christenson, P. G. Woodruff, W. E. Finkbeiner, D. J. Erle

This study shows IL-13 reduces SARS-CoV-2 infection in bronchial epithelial cells by altering gene expression and inhibiting viral replication.

bioRxiv · Feb 25, 2021Cell Biology

A defect in COPI-mediated transport of STING causes immune dysregulation in COPA syndrome

A. K. Shum, Z. Deng, Z. Chong, C. S. Law, K. Mukai, F. O. Ho, T. Martinu, B. J. Backes, W. L. Eckalbar, T. Taguchi

This study shows that defective COPI transport of STING due to COPA mutations leads to immune dysregulation and type I interferon signaling in COPA syndrome.

bioRxiv · May 20, 2020Immunology

Flow cytometric analysis and purification of airway epithelial cell subsets

L. R. Bonser, K. D. Koh, K. Johansson, S. P. Choksi, D. Cheng, L. Liu, D. I. Sun, L. T. Zlock, W. L. Eckalbar, W. E. Finkbeiner, D. J. Erle

The paper develops flow cytometric panels to isolate human airway epithelial subsets using scRNA-seq data and cell type markers, identifying subpopulations and low-abundance transcripts in secretory cells.

bioRxiv · Apr 20, 2020Cell Biology

CD161 mediates prenatal immune suppression of IFNγ-producing PLZF+ T cells

J. Halkias, E. Rackaityte, D. Aran, V. F. Mendoza, W. L. Eckalbar, T. D. Burt

The paper identifies CD161-mediated suppression of IFNγ-producing PLZF+ T cells in the human fetal intestine, highlighting their role in prenatal immune regulation.

bioRxiv · Apr 21, 2018Immunology