L. Tonggu

Structural basis for voltage-sensor trapping of the cardiac sodium channel by a deathstalker scorpon toxin

This study reveals the structure of a scorpion toxin bound to a cardiac sodium channel, showing how it traps the voltage sensor and alters channel gating without opening the channel.

Cryo-EM sample preparation method for extremely low concentration liposomes

This paper describes a cryo-EM sample preparation method that increases liposome density in EM grids using long incubation, enabling structural studies of liposomes and membrane proteins at low concentrations.

Broken symmetry in the human BK channel

The paper determines the structure of the human BK channel using cryo-EM and observes a two-fold symmetry instead of the typical four-fold symmetry in ligand-modulated ion channels.