N. Zheng

Inter-domain flexibility in F-Box proteins revealed by integrative modeling

The paper uses integrative modeling to reveal inter-domain flexibility in F-box proteins, showing varying conformational dynamics across different F-box proteins.

An artificial intelligence accelerated virtual screening platform for drug discovery

The paper develops RosettaVS, an AI-accelerated virtual screening platform that identifies drug candidates with high binding affinity across two targets, achieving a 14% and 44% hit rate in under seven days.

LRRK2 G2019S mutation suppresses differentiation of Th9 and Treg cells via JAK/STAT3

This study shows that the LRRK2 G2019S mutation impairs Th9 and Treg cell differentiation while enhancing Th2 differentiation through JAK/STAT3 signaling in T cells.

FASlpr gene dosage tunes the extent of lymphoproliferation and T cell differentiation in lupus

This study shows that FASlpr gene dosage affects lymphoproliferation and T cell differentiation in lupus models, with heterozygous Faslpr leading to increased autoantibodies and Th1 cell skewing.

Proteomic Stratification of Prognosis and Treatment Options for Small Cell Lung Cancer

This study uses proteomic profiling to stratify small cell lung cancer into three subtypes with distinct clinical outcomes and treatment responses, identifying potential therapeutic targets and improving prognosis prediction.

Commensal microbiome dysbiosis elicits IL-8 signaling to drive fibrotic skin disease

The paper investigates the role of commensal microbiome dysbiosis in keloid fibrosis, finding elevated IL-8 signaling drives collagen accumulation and fibroblast migration.

Inhibition of ADORA1 attenuates hepatic steatosis by gut microbiota-derived acetic acid from Astragalus polysaccharides

The paper reports that some data could not be replicated and the manuscript was withdrawn, with parts of the data published elsewhere.

Wireless Neuromodulation at Submillimeter Precision via a Microwave Split-Ring Resonator

This paper introduces a microwave split-ring resonator that enables submillimeter precision neuromodulation by enhancing microwave field localization and efficiency for inhibiting neurons.

Structure of IgG-Fc hexamer reveals a mutual lock-and-key mode of Fc-Fc interaction

The paper determines the structure of an IgG-Fc hexamer using cryo-EM, revealing a mutual lock-and-key interaction mode between Fc domains.

Sumoylation of the human histone H4 tail inhibits p300-mediated transcription by RNA polymerase II in cellular extracts

This study shows that sumoylation of H4K12 inhibits p300-mediated transcription and H3K4 methylation in vitro.

Structural basis for voltage-sensor trapping of the cardiac sodium channel by a deathstalker scorpon toxin

This study reveals the structure of a scorpion toxin bound to a cardiac sodium channel, showing how it traps the voltage sensor and alters channel gating without opening the channel.

Existence and Features of the Myodural Bridge in Gentoo Penguins: a morphological study

This study investigates the existence and characteristics of the myodural bridge in Gentoo penguins, finding it analogous to humans but with unique features.

Gamma secretase inhibitors inhibit ovarian cancer development and enhance olaparib's anti-ovarian cancer activity and its mechanism

This study shows that gamma secretase inhibitors reduce ovarian cancer growth and boost olaparib's effectiveness by targeting the Notch/jagged1 and Wnt/beta-catenin pathways.

ITPK1-Dependent Inositol Polyphosphates Regulate Auxin Responses in Arabidopsis thaliana

This study shows that ITPK1 produces 5-InsP7, which binds to auxin receptors and influences plant growth responses.

Repression by the Arabidopsis TOPLESS corepressor requires association with the core Mediator complex

This study identifies a repression domain in Arabidopsis TPL that interacts with Mediator subunits, essential for transcription repression in yeast and plants.

Structural changes in the gut microbiome of short-term and long-term medical workers compared to normal controls

This study compares the gut microbiome of short-term and long-term medical workers to normal controls, finding significant structural changes linked to hospital exposure.

Variations of gut microbiome profile under different storage conditions and preservation periods: A multi-dimensional evaluation

This study evaluates how different storage conditions, preservation periods, and sequencing platforms affect gut microbiome profiles using 16S rRNA gene sequencing.

Protein dynamics regulate distinct biochemical properties of cryptochromes in mammalian circadian rhythms

The paper identifies a dynamic loop in cryptochromes that regulates their differential binding to CLOCK:BMAL1, explaining their distinct roles in circadian rhythms.

Structural Basis of H2B Ubiquitination-Dependent H3K4 Methylation by COMPASS

This study determines the cryo-EM structure of the COMPASS complex bound to H2Bub and nucleosome, revealing how H2Bub activates H3K4 methylation by modulating the Set1 ARM.

Bipartite anchoring of SCREAM enforces stomatal initiation by coupling MAP Kinases to SPEECHLESS

The paper identifies SCREAM as a scaffold that recruits MPK3/6 to downregulate SPEECHLESS, enforcing stomatal initiation through a bipartite motif interaction.