W. A. Catterall

Structural basis for voltage-sensor trapping of the cardiac sodium channel by a deathstalker scorpon toxin

This study reveals the structure of a scorpion toxin bound to a cardiac sodium channel, showing how it traps the voltage sensor and alters channel gating without opening the channel.

Broadband Tuning the Voltage Dependence of a Sodium Channel

This paper shows how to shift the voltage dependence of a sodium channel's activation and gating charge movement across a wide range by engineering chimeric channels and mutations.