Gluconeogenic Enzyme PCK1 Deficiency Is Critical for CHK2 O-GlcNAcylation and Hepatocellular Carcinoma Growth upon Glucose Deprivation
J. Xiang, C. Chen, R. Liu, D. Gou, L. Chang, H. Deng, Q. Gao, W. Zhang, L. Tuo, X. Pan, L. Liang, J. Xia, L. Huang, A. Huang, K. Wang, N. Tang
This study shows that PCK1 deficiency increases O-GlcNAcylation and promotes HCC growth under glucose deprivation by enhancing CHK2 activity.
bioRxiv · Aug 6, 2020Cancer Biology