Author

L. Villiger

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 3

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:protein design· 1

Frequent Co-Authors

E. I. Ioannidi· 2 shared G. Schwank· 2 shared L. Schmidheini· 2 shared T. Rothgangl· 2 shared A. Cremonesi· 1 shared A. E. Zepeda· 1 shared A. P. Kadina· 1 shared A. Talas· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBioengineering

E. I. Ioannidi

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Author profile →

3 papers

Recent·Most cited

Treatment of a genetic liver disease in mice through transient prime editor expression

T. Rothgangl, E. I. Ioannidi, Y. Weber, A. Talas, D. Boeck, M. Matsushita, E. A. Villiger, L. Schmidheini, J. Moon, P. J. C. Lin, S. H. Y. Fan, K. F. Marquart, C. Schwerdel, N. Rimann, E. Faccin, , G. Schwank

This paper demonstrates transient prime editor expression in mice to correct a genetic liver disease, reducing blood phenylalanine levels below the therapeutic threshold.

bioRxiv · Jan 22, 2024 · PreprintBioengineering

Drag-and-drop genome insertion without DNA cleavage with CRISPR-directed integrases

E. I. Ioannidi, M. T. N. Yarnall, C. Schmitt-Ulms, R. N. Krajeski, J. Lim, L. Villiger, W. Zhou, K. Jiang, N. Roberts, L. Zhang, C. A. Vakulskas, J. A. Walker, A. P. Kadina, A. E. Zepeda, K. Holden, , O. O. Abudayyeh

PASTE enables efficient, programmable gene integration without DNA breaks, applicable for research, cell engineering, and gene therapy.

bioRxiv · Nov 1, 2021 · PreprintBioengineering

Replacing the SpCas9 HNH domain by deaminases generates compact base editors with an alternative targeting scope

L. Villiger, L. Schmidheini, N. Mathis, T. Rothgangl, K. Marquart, G. Schwank

This study replaces the SpCas9 HNH domain with deaminases to create smaller base editors with expanded targeting scope.

bioRxiv · Nov 9, 2020Bioengineering