Author

T. Rothgangl

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

G. Schwank· 3 shared K. F. Marquart· 2 shared L. Schmidheini· 2 shared L. Villiger· 2 shared M. Kopf· 2 shared A. Cremonesi· 1 shared A. Talas· 1 shared B. Thoeny· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersBioengineering

G. Schwank

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Treatment of a genetic liver disease in mice through transient prime editor expression

T. Rothgangl, E. I. Ioannidi, Y. Weber, A. Talas, D. Boeck, M. Matsushita, E. A. Villiger, L. Schmidheini, J. Moon, P. J. C. Lin, S. H. Y. Fan, K. F. Marquart, C. Schwerdel, N. Rimann, E. Faccin, , G. Schwank

This paper demonstrates transient prime editor expression in mice to correct a genetic liver disease, reducing blood phenylalanine levels below the therapeutic threshold.

bioRxiv · Jan 22, 2024 · PreprintBioengineering

Loss of Rnf31 and Vps4b sensitizes pancreatic cancer to T cell-mediated killing

N. Frey, L. Tortola, D. Egli, S. Janjuha, K. F. Marquart, T. Rothgangl, F. Ampenberger, M. Kopf, G. Schwank

This study identifies Rnf31 and Vps4b as factors enabling pancreatic cancer to evade T cell killing, showing their inactivation increases T cell-mediated tumor cell death.

bioRxiv · Jul 29, 2021Cancer Biology

Replacing the SpCas9 HNH domain by deaminases generates compact base editors with an alternative targeting scope

L. Villiger, L. Schmidheini, N. Mathis, T. Rothgangl, K. Marquart, G. Schwank

This study replaces the SpCas9 HNH domain with deaminases to create smaller base editors with expanded targeting scope.

bioRxiv · Nov 9, 2020Bioengineering