M. Matsushita

Treatment of a genetic liver disease in mice through transient prime editor expression

This paper demonstrates transient prime editor expression in mice to correct a genetic liver disease, reducing blood phenylalanine levels below the therapeutic threshold.

Monitoring plasma nucleosome concentrations to measure of disease response and progression in dogs with hematopoietic malignancies.

This study measures plasma nucleosome concentrations in dogs with hematopoietic malignancies to assess treatment response and disease progression, finding higher concentrations correlate with worse outcomes.

In macrophages fatty acid oxidation spares glutamate for use in diverse metabolic pathways required for alternative activation

This study shows that fatty acid oxidation in macrophages supports alternative activation by maintaining glutamate levels, and that glutamine metabolism compensates for FAO disruption.

Aboveground biomass increments over 26 years (1993-2019) in an old-growth cool-temperate forest in northern Japan

This study tracks 26-year aboveground biomass changes in a Japanese old-growth forest, finding steady increases driven by compensating growth and climate factors.

Novel TREM2 splicing isoform that lacks the V-set immunoglobulin domain is abundant in the human brain

The paper identifies a novel TREM2 splice isoform lacking the V-set immunoglobulin domain, which is expressed in the human brain and may affect TREM2 receptor function.

Triacylglycerol synthesis enhances macrophage inflammatory function

This study shows that triacylglycerol synthesis in macrophages is essential for inflammatory function, as inhibiting it reduces proinflammatory cytokines and phagocytic capacity.