Author

L. Y. El-Sharkawy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Approach:biophysical modeling· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

D. Brough· 2 shared J. P. Green· 2 shared S. Freeman· 2 shared A. D. Adamson· 1 shared A. Leach· 1 shared A. Liesz· 1 shared C. Lawrence· 1 shared J. Beswick· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersImmunology

D. Brough

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2 papers

Recent·Most cited

ImmunologybioRxivJul 28, 2022

Discovery of an AIM2 inflammasome inhibitor for the treatment of DNA-driven inflammatory disease.

J. P. Green, L. Y. El-Sharkawy, S. Roth…·D. Brough

The paper identifies inhibitors of DNA sensors like AIM2, cGAS, and TLR9, including 4-sulfonic calixarenes and suramin, showing potential for treating DNA-driven inflammatory diseases.

DOI 10.1016/j.isci.2023.106758

experimental assaybiophysical modeling

𝕏 PostBluesky

ImmunologybioRxivJun 11, 2020

LRRC8A regulates hypotonicity-induced NLRP3 inflammasome activation

J. P. Green, T. Swanton, L. V. Morris…·D. Brough

This study identifies LRRC8A as a key regulator of hypotonicity-induced NLRP3 inflammasome activation, distinct from DAMP-induced activation.

DOI 10.7554/elife.59704

experimental assayhost-pathogen & immune response

𝕏 PostBluesky