Author
Primary ORCID profile (0000-0003-1108-3422 · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
7 papers
Recent·Most cited
T. A. Gleeson, C. Kaiser, C. B. Lawrence, D. Brough, S. M. Allan, J. P. Green
This study shows the NLRP3 inflammasome is crucial for IL-18 production in a murine model of MAS but not for other disease features.
bioRxiv · Feb 27, 2024Immunology
R. Wellens, V. S. Tapia, H. Bennett, A. Adamson, J. Rivers-Auty, J. P. Green, G. Lopez-Castejon, D. Brough, C. Hoyle
The paper investigates the nuclear role of pro-IL-1 and evolutionary changes in its NLS and HAT-binding domains using proximity labelling and mutation analysis.
bioRxiv · Jun 26, 2023Immunology
J. Cao, S. Roth, S. Zhang, A. Kopczak, M. K. Georgakis, X. Li, A. Dutsch, T. G. Liman, M. Endres, D. Brough, J. P. Green, S. R. Wernsdorf, C. Fürle, O. Carofiglio, J. Zhu, , A. Liesz
This study shows stroke triggers inflammasome-dependent atherosclerotic plaque rupture, leading to recurrent stroke, and identifies DNA-mediated inflammasome activation as a therapeutic target.
bioRxiv · Feb 1, 2023 · PreprintImmunology
J. P. Green, L. Y. El-Sharkawy, S. Roth, J. Zhu, J. Cao, A. Leach, A. Liesz, S. Freeman, D. Brough
The paper identifies inhibitors of DNA sensors like AIM2, cGAS, and TLR9, including 4-sulfonic calixarenes and suramin, showing potential for treating DNA-driven inflammatory diseases.
bioRxiv · Jul 28, 2022Immunology
M. Roper, J. P. Green, R. Salguero-Gomez, M. B. Bonsall
This paper derives inclusive fitness forces of selection in social species, showing that selection on survival can persist post-reproduction and reproductive selection may not decline monotonically.
bioRxiv · Jun 2, 2022Evolutionary Biology
C. Hoyle, J. P. Green, S. M. Allan, D. Brough, E. Lemarchand
This study shows itaconate and fumarate derivatives inhibit both priming and activation of NLRP3 inflammasome in macrophages and microglia, suggesting their therapeutic potential for NLRP3-driven diseases.
bioRxiv · Feb 1, 2021Immunology
J. P. Green, T. Swanton, L. V. Morris, L. Y. El-Sharkawy, J. Cook, S. Yu, J. Beswick, A. D. Adamson, N. E. Humphreys, R. Bryce, S. Freeman, C. Lawrence, D. Brough
This study identifies LRRC8A as a key regulator of hypotonicity-induced NLRP3 inflammasome activation, distinct from DAMP-induced activation.
bioRxiv · Jun 11, 2020Immunology