Lung cancer-intrinsic SOX2 expression mediates resistance to checkpoint blockade therapy by inducing Treg-dependent CD8+ T cell exclusion
E. Torres-Mejia, S. Weng, K. B. Nguyen, E. Duong, L. Yim, S. Spranger
This study identifies SOX2 expression in lung cancer cells as a mechanism causing resistance to checkpoint blockade by promoting Treg-dependent CD8+ T cell exclusion.
bioRxiv · Sep 6, 2023Immunology