Author

K. B. Nguyen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

S. Spranger· 2 shared B. Kim· 1 shared C. J. Copeland· 1 shared C. M. Backlund· 1 shared D. J. Irvine· 1 shared E. Duong· 1 shared E. Torres-Mejia· 1 shared L. Yim· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersImmunology

S. Spranger

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Author profile →

2 papers

Recent·Most cited

Lung cancer-intrinsic SOX2 expression mediates resistance to checkpoint blockade therapy by inducing Treg-dependent CD8+ T cell exclusion

E. Torres-Mejia, S. Weng, K. B. Nguyen, E. Duong, L. Yim, S. Spranger

This study identifies SOX2 expression in lung cancer cells as a mechanism causing resistance to checkpoint blockade by promoting Treg-dependent CD8+ T cell exclusion.

bioRxiv · Sep 6, 2023Immunology

Decoupled neoantigen cross-presentation in tumors with high intratumor heterogeneity reduces dendritic cell activation to limit anti-tumor immunity

K. B. Nguyen, C. J. Copeland, C. M. Backlund, N. G. Klop-Packel, T. Remba, B. Kim, N. K. Singh, M. E. Birnbaum, D. J. Irvine, S. Spranger

This study shows that clonal neoantigen expression enhances dendritic cell activation and anti-tumor immunity, while subclonal expression reduces it in tumors with high intratumor heterogeneity.

bioRxiv · Dec 16, 2022Immunology