Selective IL-27 production by intestinal regulatory T cells permits gut-specific regulation of Th17 immunity
C.-H. Lin, C.-J. Wu, S. Cho, R. Patkar, L.-L. Lin, M.-C. Chen, E. Israelsson, J. Betts, M. Niedzielska, S. A. Patel, H. G. Duong, R. R. Gerner, C.-Y. Hsu, M. Catley, R. A. Maciewicz, , L.-F. Lu
This study identifies intestinal regulatory T cells producing IL-27 to specifically regulate Th17 immunity in the gut, revealing a novel mechanism for tissue-specific immune control.
bioRxiv · Feb 20, 2023Immunology