C.-H. Lin

Cross-institutional HER2 assessment via a computer-aided system using federated learning and stain composition augmentation

This paper develops a HER2 assessment system using federated learning and stain composition augmentation, achieving over 90% accuracy across two institutions with improved generalizability.

Selective IL-27 production by intestinal regulatory T cells permits gut-specific regulation of Th17 immunity

This study identifies intestinal regulatory T cells producing IL-27 to specifically regulate Th17 immunity in the gut, revealing a novel mechanism for tissue-specific immune control.

Measuring factors affecting honey bee attraction to soybeans using bioacoustics monitoring

This study uses bioacoustics monitoring to detect honey bee activity in soybean fields, finding that bee presence varies with blooming status and soybean variety.

Proximity-dependent labeling identifies dendritic cells that drive the tumor-specific CD4+ T cell response

The paper identifies dendritic cells that present antigens to CD4+ T cells in tumor-draining lymph nodes and the tumor microenvironment using LIPSTIC-based single-cell transcriptomics.

A machine learning liver-on-a-chip system for safer drug formulation

This paper develops a liver-on-a-chip system combined with machine learning to model drug metabolism and identify excipients that reduce hepatotoxicity in vivo.

Transcriptomes and metabolism define mouse and human MAIT cell heterogeneity

This study identifies MAIT cell heterogeneity in mice and humans through single-cell RNA sequencing and metabolic analysis, revealing distinct transcriptomes and metabolic states in different tissues and species.

Structural basis for Cas9 off-target activity

This study identifies structural mechanisms enabling Cas9 off-target activity through non-canonical base pairing and conformational changes.

Psychological stress disrupts intestinal epithelial cell function and mucosal integrity through microbe and host-directed processes

This study shows that psychological stress disrupts intestinal epithelial cell function and mucosal integrity in mice, mediated by microbiota and host stress signals.

Photoperiod Sensitive Energy Sorghum Responses to Environmental and Nitrogen Variabilities

This study evaluates biomass yield and feedstock quality of photoperiod-sensitive sorghum hybrids under varying nitrogen inputs and environments, finding higher yields in temperate regions with lower nitrogen requirements.

Species-specific phototaxis of coral larvae causes variation in vertical positioning during dispersal

The paper shows that P. verrucosa coral larvae use phototaxis to position themselves near the surface, while other species do not.

Distinct Inductions of and Responses to Type I and Type III Interferons PromoteInfections in Two SARS-CoV-2 Isolates

This study compares two SARS-CoV-2 isolates and finds they induce weak antiviral responses and are less neutralized by antibodies.

Honey bee pollen foraging ecology across an urbanization gradient

This study uses metabarcoding to analyze honey bee pollen foraging across an urbanization gradient, finding higher taxonomic diversity and temporal turnover in urban areas compared to agricultural ones.

Characterization of Single Protein Dynamics in Cell Plasma Membrane Derived Polymer Cushioned Lipid Bilayers

This study characterizes single membrane protein dynamics in polymer-cushioned lipid bilayers and finds that increasing polymer length enhances protein mobility and reduces transient confinement.

Long-Term Outcomes of Pediatric Graves Disease Patients Treated with Anti-Thyroid Drugs: Experience from a Taiwan Medical Center

This study examines long-term outcomes of pediatric Graves disease patients treated with anti-thyroid drugs, finding that younger age, no family history of thyroid disease, and lower TRAb levels are associated with remission.

PD-L1:CD80 Heterodimer Triggers CD28 While Repressing Both PD-1 and CTLA4 Pathways

The paper identifies a molecular crosstalk where PD-L1 and CD80 form a heterodimer, blocking inhibitory pathways but preserving CD28 activation, and shows how PD-L1 blockade affects CD80 expression.