Structural Determinants for Activity of the Antidepressant Vortioxetine at Human and Rodent 5-HT3 receptors
Uriel López-Sánchez, Lachlan Jake Munro, Lucy Kate Ladefoged, Anders Juel Pedersen, Christian Colding Brun, Signe Meisner Lyngby, Delphine Baud, Céline Juillan‐Binard, Miriam Grønlund Pedersen, Sarah C. R. Lummis, Benny Bang‐Andersen, Birgit Schiøtt, Christophe J. Chipot, Guy Schoehn, Jacques Neyton, , Anders S. Kristensen
This study investigates how vortioxetine interacts with human and rodent 5-HT3 receptors, revealing structural differences and mechanisms of action.
Nature Structural & Molecular Biology · May 2, 2024Peer-reviewedBiochemistry